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Title Page

Review Article 


Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review

Mohamed Helmy Salama.


Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions globally. Periodontal ligament stem cells (PDLSCs) and dental pulp stem cells (DPSCs) have shown promise beyond dental tissue regeneration, potentially offering therapeutic benefits for neurodegenerative disorders such as AD. This scoping review aimed to map the global evidence on the therapeutic effects of PDLSC and DPSC on AD, following the JBI methodology and Arksey and O’Malley’s 2005 framework. Studies focused on PDLSC and DPSC in AD were included, excluding opinion papers and review articles. Comprehensive searches in PubMed, Web of Science, and SCOPUS up to October 30, 2024, yielded relevant studies, which were collated and managed using ENDNOTE 20. Data were extracted using online tool. The review aggregates current evidence on the therapeutic effects and mechanisms of PDLSC and DPSC in AD treatment, highlighting potential benefits and identifying literature gaps. Despite promising findings, further research is necessary to substantiate these benefits. The review also suggests conceptual and methodological strategies for future studies to address limitations and clarify the roles of these stem cells in AD treatment.

Key words: Alzheimer’s disease, Neurogenesis, Stem cells, Periodontal ligament, Dental pulp


 
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Pubmed Style

Mohamed Helmy Salama. Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah J Heal Sci. 2025; 13(3): 120-155. doi:10.5455/mjhs.2025.03.012

Web Style

Mohamed Helmy Salama. Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. https://www.mjhs-mu.org/?mno=235290 [Access: June 22, 2026]. doi:10.5455/mjhs.2025.03.012

AMA (American Medical Association) Style

Mohamed Helmy Salama. Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah J Heal Sci. 2025; 13(3): 120-155. doi:10.5455/mjhs.2025.03.012


Vancouver/ICMJE Style

Mohamed Helmy Salama. Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah J Heal Sci. (2025), [cited June 22, 2026]; 13(3): 120-155. doi:10.5455/mjhs.2025.03.012


Harvard Style

Mohamed Helmy Salama (2025) Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah J Heal Sci, 13 (3), 120-155. doi:10.5455/mjhs.2025.03.012


Turabian Style

Mohamed Helmy Salama. 2025. Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah Journal of Health Sciences, 13 (3), 120-155. doi:10.5455/mjhs.2025.03.012


Chicago Style

Mohamed Helmy Salama. "Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review." Majmaah Journal of Health Sciences 13 (2025), 120-155. doi:10.5455/mjhs.2025.03.012


MLA (The Modern Language Association) Style

Mohamed Helmy Salama. "Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review." Majmaah Journal of Health Sciences 13.3 (2025), 120-155. Print. doi:10.5455/mjhs.2025.03.012


APA (American Psychological Association) Style

Mohamed Helmy Salama (2025) Periodontal ligament stem cell and dental pulp stem cell’s therapeutic potential in Alzheimers disease- A systematic scoping review. Majmaah Journal of Health Sciences, 13 (3), 120-155. doi:10.5455/mjhs.2025.03.012




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