Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients

Nadeem Afzal; Khursheed Javaid; Shahid Hussain; Saleem-uz-Zaman Adahmi; Waqas Sami; Ihtzaz Ahmed Malik

doi:10.12816/0004779

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Majmaah J Heal Sci. 2014; 2(1): 15-20

doi: 10.12816/0004779

Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik.

Abstract
Background & Objectives: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. All over the world TB is one of the leading causes of mortality and morbidity. Interferon-gamma (IFN-γ), at the site of MTB infection, activates macrophages to kill intracellular mycobacteria. CD8+ T cells kill the cells infected by viruses and other intracellular microbes. Diagnostic significance of IFN-γ has been reviewed in latent and active TB. Aim of this study was to determine association between IFN-γ and CD8+ T-cells in the blood of pulmonary TB-patients.

Methods: Study consisted of 54-TB-patients and 38 healthy subjects. Level of IFN-γ was determined by ELISA and percentage of CD8+ T-cells by flow cytometry.

Results: Level of IFN-γ and percentage of CD8+ T-lymphocytes were high in the blood of TB patients compared to control.

Conclusion: TB patients had high level of IFN-γ compared to healthy controls. IFN-γ and CD8+ T cells were negatively correlated with duration of treatment of tuberculosis. There was no difference in percentage of CD8+ T cells in TB patients after 3 months of chemotherapy compared to controls.

Key words: Interferon gamma, Tuberculosis, CD8+ T lymphocytes

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How to Cite this Article

Pubmed Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20. doi:10.12816/0004779

Web Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. https://www.mjhs-mu.org/?mno=289902 [Access: December 05, 2023]. doi:10.12816/0004779

AMA (American Medical Association) Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20. doi:10.12816/0004779

Vancouver/ICMJE Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. (2014), [cited December 05, 2023]; 2(1): 15-20. doi:10.12816/0004779

Harvard Style

Afzal, N., Javaid, . K., Hussain, . S., Adahmi, . S., Sami, . W. & Malik, . I. A. (2014) Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci, 2 (1), 15-20. doi:10.12816/0004779

Turabian Style

Afzal, Nadeem, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, and Ihtzaz Ahmed Malik. 2014. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah Journal of Health Sciences, 2 (1), 15-20. doi:10.12816/0004779

Chicago Style

Afzal, Nadeem, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, and Ihtzaz Ahmed Malik. "Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients." Majmaah Journal of Health Sciences 2 (2014), 15-20. doi:10.12816/0004779

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