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Review Article 


Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation

Jobran M Moshi.


Abstract
Epigenetics, a rapidly developing field within genetics, involves the study of heritable alterations in gene expression that are not caused by changes in the DNA sequence. Notable modifications include histone modifications, non-coding RNA, and DNA methylation molecules, which collectively regulate gene expression without modifying the genetic code. This review underscores the influence of physiological, pathological, and environmental factors on these modifications, utilizing Angelman syndrome and Rett syndrome as examples. Furthermore, this review highlights the broader impact of epigenetic alterations caused by lifestyle choices, including smoking and poor diet, on increasing the probability of chronic illnesses such as diabetes and cancer. The dynamic nature of epigenetic regulation emphasizes the need to consider environmental and lifestyle factors in understanding complex diseases, such as Angelman syndrome, offering significant implications for both etiological comprehension and the development of potential therapeutic interventions.

Key words: Epigenetics, Gene Expression, DNA Methylation, Angelman Syndrome, Rett Syndrome


 
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Pubmed Style

Jobran M Moshi. Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah J Heal Sci. 2025; 13(2): 181-197. doi:10.5455/mjhs.2025.02.015

Web Style

Jobran M Moshi. Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. https://www.mjhs-mu.org/?mno=225300 [Access: April 16, 2025]. doi:10.5455/mjhs.2025.02.015

AMA (American Medical Association) Style

Jobran M Moshi. Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah J Heal Sci. 2025; 13(2): 181-197. doi:10.5455/mjhs.2025.02.015


Vancouver/ICMJE Style

Jobran M Moshi. Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah J Heal Sci. (2025), [cited April 16, 2025]; 13(2): 181-197. doi:10.5455/mjhs.2025.02.015


Harvard Style

Jobran M Moshi (2025) Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah J Heal Sci, 13 (2), 181-197. doi:10.5455/mjhs.2025.02.015


Turabian Style

Jobran M Moshi. 2025. Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah Journal of Health Sciences, 13 (2), 181-197. doi:10.5455/mjhs.2025.02.015


Chicago Style

Jobran M Moshi. "Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation." Majmaah Journal of Health Sciences 13 (2025), 181-197. doi:10.5455/mjhs.2025.02.015


MLA (The Modern Language Association) Style

Jobran M Moshi. "Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation." Majmaah Journal of Health Sciences 13.2 (2025), 181-197. Print. doi:10.5455/mjhs.2025.02.015


APA (American Psychological Association) Style

Jobran M Moshi (2025) Exploring the Epigenetic Landscape: Unraveling the Intricacies of Gene Regulation. Majmaah Journal of Health Sciences, 13 (2), 181-197. doi:10.5455/mjhs.2025.02.015




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