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Original Research (Original Article) 


Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma

Abdelraheem R. Elgendy, Mohamed H. Salama, S. Karthiga Kannan.

Abstract
Objectives: The current research aimed to evaluate the role of fine needle aspiration biopsy (FNAB) and CD3, CD20 and CD45 in the identification of oral primary diffuse large B-cell lymphoma (DLBCL).

Materials and methods: This is a descriptive clinical study. Ten patients clinically diagnosed as DLBCL in a tertiary level hospital in Qassim, Saudi Arabia; were included. Fine needle aspiration and incisional biopsies were taken from each patient and processed in the appropriate manner. Histopathological confirmation was done using haematoxylin and eosin stained specimens. Other sections were taken for the immune histochemistry using a standard strept-avidin-biotin peroxidase procedure and monoclonal antibodies, including CD3, CD20 and CD45.

Results: The obtained results showed positivity of FNAB in 7 cases and three cases were inconclusive. Strong positive immune reaction was revealed with CD20 and CD45, while CD3 was negative in all studied cases.

Conclusion: These findings indicated the diagnostic significance of FNAB, CD20 CD45 and CD3 in proper diagnosis of oral DLBCL. More research is necessary for predicting the prognostic importance of these molecular markers in oral lymphomas.

Key words: B-cell lymphoma, CD3, CD20, CD45, FNAB


 
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How to Cite this Article
Pubmed Style

Elgendy AR, Salama MH, Kannan SK. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. 2018; 6(2): 10-21. doi:10.5455/mjhs.2018.02.003


Web Style

Elgendy AR, Salama MH, Kannan SK. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. http://www.mjhs-mu.org/?mno=302643524 [Access: May 01, 2020]. doi:10.5455/mjhs.2018.02.003


AMA (American Medical Association) Style

Elgendy AR, Salama MH, Kannan SK. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. 2018; 6(2): 10-21. doi:10.5455/mjhs.2018.02.003



Vancouver/ICMJE Style

Elgendy AR, Salama MH, Kannan SK. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci. (2018), [cited May 01, 2020]; 6(2): 10-21. doi:10.5455/mjhs.2018.02.003



Harvard Style

Elgendy, A. R., Salama, . M. H. & Kannan, . S. K. (2018) Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah J Heal Sci, 6 (2), 10-21. doi:10.5455/mjhs.2018.02.003



Turabian Style

Elgendy, Abdelraheem R., Mohamed H. Salama, and S. Karthiga Kannan. 2018. Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah Journal of Health Sciences, 6 (2), 10-21. doi:10.5455/mjhs.2018.02.003



Chicago Style

Elgendy, Abdelraheem R., Mohamed H. Salama, and S. Karthiga Kannan. "Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma." Majmaah Journal of Health Sciences 6 (2018), 10-21. doi:10.5455/mjhs.2018.02.003



MLA (The Modern Language Association) Style

Elgendy, Abdelraheem R., Mohamed H. Salama, and S. Karthiga Kannan. "Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma." Majmaah Journal of Health Sciences 6.2 (2018), 10-21. Print. doi:10.5455/mjhs.2018.02.003



APA (American Psychological Association) Style

Elgendy, A. R., Salama, . M. H. & Kannan, . S. K. (2018) Application of Fine Needle Aspiration Biopsy and Immunohistochemical Diagnostic Markers in the Identification of Oral Primary B-cell Lymphoma. Majmaah Journal of Health Sciences, 6 (2), 10-21. doi:10.5455/mjhs.2018.02.003





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