ISSN 1658-645X
 

Original Research (Original Article) 


Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats

Rehan M Asad, Moattar R Rizvi, Sami Waqas, Kamran Afzal.

Abstract
Background: Aminoglycoside-induced nephrotoxicity and ototoxicity is a major clinical problem. Aminoglycosides have good activity against many multi-drug resistant Gram-negative bacilli and are therefore important for treating serious infections due to these organisms in adults and children including neonates. Gentamicin, due to it cost effectiveness has been used in most of the trials as compared to other aminoglycosides. Most studies documented the peripheral toxicities of gentamicin without any concern of central neurotoxicity.

Objective: To observe Gentamicin induced neurodegenerative changes in auditory cortex of adult albino rats.

Methods: It was an experimental study. Twenty rats were randomly divided in two groups; Group I (Experimental: n = 10) received intramuscular injection of Gentamicin for twenty-one days and Group II (Control: n =10) received normal saline intramuscularly. Histological preparations were done on sections obtained from the area around lateral sulcus of rat cortex. The photomicrographs of the relevant stained sections were taken with the aid of a light microscope.

Results: Light microscopic examination of the auditory cortex sections obtained from gentamicin injected rats (Group I) revealed severe neurodegenerative changes as compared to the rats in (Group II).

Conclusion: Exposure of rats to Gentamicin for three weeks showed severe neurodegenerative changes.

Key words: Aminoglycosides, Auditory Cortex, Nephrotoxicity, Ototoxicity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Rehan M Asad
Articles by Moattar R Rizvi
Articles by Sami Waqas
Articles by Kamran Afzal
on Google
on Google Scholar
Article Statistics
 Viewed: 258
Downloaded: 28
Cited: 0

How to Cite this Article
Pubmed Style

Asad RM, Rizvi MR, Waqas S, Afzal K. Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah J Heal Sci. 2013; 1(1): 11-17.


Web Style

Asad RM, Rizvi MR, Waqas S, Afzal K. Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. http://www.mjhs-mu.org/?mno=287957 [Access: July 21, 2018].


AMA (American Medical Association) Style

Asad RM, Rizvi MR, Waqas S, Afzal K. Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah J Heal Sci. 2013; 1(1): 11-17.



Vancouver/ICMJE Style

Asad RM, Rizvi MR, Waqas S, Afzal K. Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah J Heal Sci. (2013), [cited July 21, 2018]; 1(1): 11-17.



Harvard Style

Asad, R. M., Rizvi, M. R., Waqas, S. & Afzal, K. (2013) Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah J Heal Sci, 1 (1), 11-17.



Turabian Style

Asad, Rehan M, Moattar R Rizvi, Sami Waqas, and Kamran Afzal. 2013. Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah Journal of Health Sciences, 1 (1), 11-17.



Chicago Style

Asad, Rehan M, Moattar R Rizvi, Sami Waqas, and Kamran Afzal. "Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats." Majmaah Journal of Health Sciences 1 (2013), 11-17.



MLA (The Modern Language Association) Style

Asad, Rehan M, Moattar R Rizvi, Sami Waqas, and Kamran Afzal. "Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats." Majmaah Journal of Health Sciences 1.1 (2013), 11-17. Print.



APA (American Psychological Association) Style

Asad, R. M., Rizvi, M. R., Waqas, S. & Afzal, K. (2013) Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats. Majmaah Journal of Health Sciences, 1 (1), 11-17.





Most Viewed Articles
  • Animal Models of Non Cirrhotic Portal Hypertension (NCPH)
    Moattar R Rizvi
    Majmaah J Heal Sci. 2013; 1(1): 58-70
    » Abstract

  • CDP-Choline Neuroprotection and Vascular Remodeling via IRS-1 mechanisms in Vascular Dementia - Growing Neurons ATOP Microelectronic chips as a new model for Neurodegeneration
    Raid Al-Baradie, Stephen Lynch, J Borresen, Jerzy Krupinski, Mark Slevin
    Majmaah J Heal Sci. 2013; 1(1): 5-10
    » Abstract

  • Preface
    Mohammad Othman Al Rukban
    Majmaah J Heal Sci. 2013; 1(1): -
    » Abstract

  • Recent Insights into Nosocomial Infections - A Neglected Condition
    Nasser Jarallah
    Majmaah J Heal Sci. 2013; 1(1): 53-57
    » Abstract

  • Roach’s Type II Variant of Sturge – Weber Syndrome: A Case Report
    Saleem Shaikh, Abdur Rahman Al-Atram, Sachdeva Harleen
    Majmaah J Heal Sci. 2013; 1(1): 71-76
    » Abstract

  • Foreword
    Khalid bin Saad Al-Meqrin
    Majmaah J Heal Sci. 2013; 1(1): -
    » Abstract

  • Medical Hypnosis – A Poorly Understood Therapeutic Modality
    Riaz Qureshi
    Majmaah J Heal Sci. 2013; 1(1): 1-4
    » Abstract

  • Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats
    Rehan M Asad, Moattar R Rizvi, Sami Waqas, Kamran Afzal
    Majmaah J Heal Sci. 2013; 1(1): 11-17
    » Abstract

  • Parental Knowledge, Attitude and Practice on Antibiotic use for Upper Respiratory Tract Infections in Children
    Khaled Al-Dossari
    Majmaah J Heal Sci. 2013; 1(1): 33-45
    » Abstract

  • The prevalence of Vitamin D deficiency in Type 2 Diabetic patients
    Mansour Al-Zaharani
    Majmaah J Heal Sci. 2013; 1(1): 18-22
    » Abstract

  • Most Downloaded
  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract

  • Prevalence of Hypertriglyceridemia in Patients Attending Primary Health Care Centers in Majmaah, Saudi Arabia
    Fahad Alfhaid
    Majmaah J Heal Sci. 2018; 6(1): 10-16
    » Abstract

  • Prevalence and Risk Factors of Hypercholesterolemia in Majmaah, Saudi Arabia
    Khalid El Tohami Medani, Mohammed Abdullah Al Mansour, Elsadig Yousif Mohamed, Fahad Alfhaid, Talal Shakhs Alghamdi, Waqas Sami, Sawsan Mustafa Abdalla, Mansour Khater Al Zahrani
    Majmaah J Heal Sci. 2018; 6(1): 34-41
    » Abstract

  • Relationship Between Vitamin-D and Obesity in Pediatric Outpatients, at King Khalid General Hospital, Majmaah, Saudi Arabia
    Fahad K. Aldhafiri
    Majmaah J Heal Sci. 2018; 6(1): 1-9
    » Abstract

  • Editorial
    Khalid Bin Mohamed Alabdulwahab
    Majmaah J Heal Sci. 2018; 6(1): -
    » Abstract

  • Use of FDG-PET/CT for Biological Target Volume Definition in Head and Neck Cancer
    Abdulrahman A Alfuraih
    Majmaah J Heal Sci. 2018; 6(1): 61-82
    » Abstract

  • Prevalence of Brucellosis in Hawtat Sudair City, Riyadh Province, Saudi Arabia
    Mohammed Alaidarous
    Majmaah J Heal Sci. 2018; 6(1): 17-25
    » Abstract

  • Upcoming Conferences

    Majmaah J Heal Sci. 2018; 6(1): 90-
    » Abstract

  • Neuromotor Development in a Girl with SERAC 1 Gene Dysfunction from Kingdom of Saudi Arabia: A case study
    Faisal Y. Asiri
    Majmaah J Heal Sci. 2018; 6(1): 42-47
    » Abstract

  • Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus
    Abdulrahman M. Alamri
    Majmaah J Heal Sci. 2018; 6(1): 26-33
    » Abstract

  • Most Cited Articles