ISSN 1658-645X
 

Original Research (Original Article) 


Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus

Abdulrahman M. Alamri.

Abstract
Objective: To evaluate the long-term safety and efficacy of corneal cross-linking in keratoconus patients with thin corneas.

Methods: Forty eyes of 25 subjects having progressive keratoconus with thinnest corneal thickness (TCT) less than 400 m were evaluated. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal topography, and endothelial cell loss were assessed at baseline and followed at six-month interval till the end of 1st year of follow up and then yearly till the fifth year, de-epithelization of cornea was performed, followed by ultrasound pachymetry to measure TCT. Hypoosmolar riboflavin (0.1%) solution was applied after every 2 minutes for 25 minutes. Ultraviolet A (UVA) irradiation was performed for 30 minutes along with riboflavin for every 2 minutes.

Results: Mean TCT was 381.5 13.2 m (range: 344396 m) without corneal epithelium. Following hypotonic riboflavin instillation, mean TCT increased by 97.8 12.1 m (range: 83112 m) for a mean thickness of 478.1 14.9 m (range: 409506 m). The average follow-up period was 61.79 6.19 months (range: 4268 months). Corrected distance visual acuity, pachymetry values and posterior elevation showed no significant difference before and after CXL at 5 years follow-up. Corneal astigmatism and maximum keratometry reading (Kmax) were significantly reduced. Mean reduction of endothelial cell count was 1.5% at the last follow-up visit.

Conclusions: CXL with UVA and hypoosmolar riboflavin was effective in stabilizing keratoconus progression in patients with thin corneas however further studies are required to confirm our results.

Key words: corneal cross-linking, keratoconus, riboflavin, thin cornea


 
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Pubmed Style

Abdulrahman M. Alamri. Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah J Heal Sci. 2018; 6(1): 26-33.


Web Style

Abdulrahman M. Alamri. Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. http://www.mjhs-mu.org/?mno=297300 [Access: May 25, 2018].


AMA (American Medical Association) Style

Abdulrahman M. Alamri. Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah J Heal Sci. 2018; 6(1): 26-33.



Vancouver/ICMJE Style

Abdulrahman M. Alamri. Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah J Heal Sci. (2018), [cited May 25, 2018]; 6(1): 26-33.



Harvard Style

Abdulrahman M. Alamri (2018) Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah J Heal Sci, 6 (1), 26-33.



Turabian Style

Abdulrahman M. Alamri. 2018. Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah Journal of Health Sciences, 6 (1), 26-33.



Chicago Style

Abdulrahman M. Alamri. "Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus." Majmaah Journal of Health Sciences 6 (2018), 26-33.



MLA (The Modern Language Association) Style

Abdulrahman M. Alamri. "Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus." Majmaah Journal of Health Sciences 6.1 (2018), 26-33. Print.



APA (American Psychological Association) Style

Abdulrahman M. Alamri (2018) Long-Term Safety and Efficacy of Corneal Cross-Linking in thin Corneas with Keratoconus. Majmaah Journal of Health Sciences, 6 (1), 26-33.





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