E-ISSN 1658-8223 | ISSN 1658-645X
 

Original Research (Original Article) 


Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik.

Abstract
Background & Objectives: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. All over the world TB is one of the leading causes of mortality and morbidity. Interferon-gamma (IFN-γ), at the site of MTB infection, activates macrophages to kill intracellular mycobacteria. CD8+ T cells kill the cells infected by viruses and other intracellular microbes. Diagnostic significance of IFN-γ has been reviewed in latent and active TB. Aim of this study was to determine association between IFN-γ and CD8+ T-cells in the blood of pulmonary TB-patients.

Methods: Study consisted of 54-TB-patients and 38 healthy subjects. Level of IFN-γ was determined by ELISA and percentage of CD8+ T-cells by flow cytometry.

Results: Level of IFN-γ and percentage of CD8+ T-lymphocytes were high in the blood of TB patients compared to control.

Conclusion: TB patients had high level of IFN-γ compared to healthy controls. IFN-γ and CD8+ T cells were negatively correlated with duration of treatment of tuberculosis. There was no difference in percentage of CD8+ T cells in TB patients after 3 months of chemotherapy compared to controls.

Key words: Interferon gamma, Tuberculosis, CD8+ T lymphocytes


 
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Pubmed Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20.


Web Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. http://www.mjhs-mu.org/?mno=289902 [Access: November 18, 2019].


AMA (American Medical Association) Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20.



Vancouver/ICMJE Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. (2014), [cited November 18, 2019]; 2(1): 15-20.



Harvard Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik (2014) Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci, 2 (1), 15-20.



Turabian Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. 2014. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah Journal of Health Sciences, 2 (1), 15-20.



Chicago Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. "Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients." Majmaah Journal of Health Sciences 2 (2014), 15-20.



MLA (The Modern Language Association) Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik. "Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients." Majmaah Journal of Health Sciences 2.1 (2014), 15-20. Print.



APA (American Psychological Association) Style

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik (2014) Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah Journal of Health Sciences, 2 (1), 15-20.





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