E-ISSN 1658-8223 | ISSN 1658-645X
 

Original Research (Original Article) 


Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients

Nadeem Afzal, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, Ihtzaz Ahmed Malik.

Abstract
Background & Objectives: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. All over the world TB is one of the leading causes of mortality and morbidity. Interferon-gamma (IFN-γ), at the site of MTB infection, activates macrophages to kill intracellular mycobacteria. CD8+ T cells kill the cells infected by viruses and other intracellular microbes. Diagnostic significance of IFN-γ has been reviewed in latent and active TB. Aim of this study was to determine association between IFN-γ and CD8+ T-cells in the blood of pulmonary TB-patients.

Methods: Study consisted of 54-TB-patients and 38 healthy subjects. Level of IFN-γ was determined by ELISA and percentage of CD8+ T-cells by flow cytometry.

Results: Level of IFN-γ and percentage of CD8+ T-lymphocytes were high in the blood of TB patients compared to control.

Conclusion: TB patients had high level of IFN-γ compared to healthy controls. IFN-γ and CD8+ T cells were negatively correlated with duration of treatment of tuberculosis. There was no difference in percentage of CD8+ T cells in TB patients after 3 months of chemotherapy compared to controls.

Key words: Interferon gamma, Tuberculosis, CD8+ T lymphocytes


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Nadeem Afzal
Articles by Khursheed Javaid
Articles by Shahid Hussain
Articles by Saleem-uz-Zaman Adahmi
Articles by Waqas Sami
Articles by Ihtzaz Ahmed Malik
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20. doi:10.12816/0004779


Web Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. http://www.mjhs-mu.org/?mno=289902 [Access: May 01, 2020]. doi:10.12816/0004779


AMA (American Medical Association) Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. 2014; 2(1): 15-20. doi:10.12816/0004779



Vancouver/ICMJE Style

Afzal N, Javaid K, Hussain S, Adahmi S, Sami W, Malik IA. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci. (2014), [cited May 01, 2020]; 2(1): 15-20. doi:10.12816/0004779



Harvard Style

Afzal, N., Javaid, . K., Hussain, . S., Adahmi, . S., Sami, . W. & Malik, . I. A. (2014) Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah J Heal Sci, 2 (1), 15-20. doi:10.12816/0004779



Turabian Style

Afzal, Nadeem, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, and Ihtzaz Ahmed Malik. 2014. Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah Journal of Health Sciences, 2 (1), 15-20. doi:10.12816/0004779



Chicago Style

Afzal, Nadeem, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, and Ihtzaz Ahmed Malik. "Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients." Majmaah Journal of Health Sciences 2 (2014), 15-20. doi:10.12816/0004779



MLA (The Modern Language Association) Style

Afzal, Nadeem, Khursheed Javaid, Shahid Hussain, Saleem-uz-Zaman Adahmi, Waqas Sami, and Ihtzaz Ahmed Malik. "Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients." Majmaah Journal of Health Sciences 2.1 (2014), 15-20. Print. doi:10.12816/0004779



APA (American Psychological Association) Style

Afzal, N., Javaid, . K., Hussain, . S., Adahmi, . S., Sami, . W. & Malik, . I. A. (2014) Inverse correlation of Interferon-gamma and CD8+ T Lymphocytes in Tuberculosis Patients. Majmaah Journal of Health Sciences, 2 (1), 15-20. doi:10.12816/0004779





Most Viewed Articles
  • Prevalence and Risk Factors of Hypercholesterolemia in Majmaah, Saudi Arabia
    Khalid El Tohami Medani, Mohammed Abdullah Al Mansour, Elsadig Yousif Mohamed, Fahad Alfhaid, Talal Shakhs Alghamdi, Waqas Sami, Sawsan Mustafa Abdalla, Mansour Khater Al Zahrani
    Majmaah J Heal Sci. 2018; 6(1): 34-41
    » Abstract » doi: 10.5455/mjhs.2018.01.006

  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract » doi: 10.5455/mjhs.2018.01.008

  • Gentamicin induced neurodegenerative changes in auditory cortex of adult Albino rats
    Rehan M Asad, Moattar R Rizvi, Sami Waqas, Kamran Afzal
    Majmaah J Heal Sci. 2013; 1(1): 11-17
    » Abstract » doi: 10.12816/0004766

  • Prevalence of Hypertriglyceridemia in Patients Attending Primary Health Care Centers in Majmaah, Saudi Arabia
    Fahad Alfhaid
    Majmaah J Heal Sci. 2018; 6(1): 10-16
    » Abstract » doi: 10.5455/mjhs.2018.01.003

  • Parental Knowledge, Attitude and Practice on Antibiotic use for Upper Respiratory Tract Infections in Children
    Khaled Al-Dossari
    Majmaah J Heal Sci. 2013; 1(1): 33-45
    » Abstract » doi: 10.12816/0004769

  • Most Downloaded
  • The Epidemiological Transmission and Double-Burden of Disease: A Focus on Africa
    Asim Abdelmoneim Hussein
    Majmaah J Heal Sci. 2014; 2(2): 3-11
    » Abstract

  • Relativity of Platelet Count with Automated Cell Counter & Manual Haemocytometer using Peripheral Blood Smear
    Purnendu Sinha, Moattar Raza Rizvi, Ranjay Kumar Choudhary
    Majmaah J Heal Sci. 2014; 2(1): 41-46
    » Abstract » doi: 10.12816/0004783

  • Physical Therapy Intervention in Post Stroke Shoulder Subluxation: A Narrative Review
    Mazen Alqahtani
    Majmaah J Heal Sci. 2018; 6(1): 48-60
    » Abstract » doi: 10.5455/mjhs.2018.01.008

  • How Many Subjects Should be Studied: Sample Size Determination through Hypothesis Testing and Confidence Interval
    Waqas Sami, Mohammed O. Al-Rukban, Mohammed Almansour, Tayyaba Waqas, Kamran Afzal, Rehan Asad
    Majmaah J Heal Sci. 2013; 1(2): 43-48
    » Abstract

  • An Assessment of Nutrition Education in Primary Schools and its Effect on Students Dietary Behaviors and Body Mass Index in Saudi Arabia
    Ali S. R. Alsubaie
    Majmaah J Heal Sci. 2017; 5(2): 45-56
    » Abstract » doi: 10.5455/mjhs.2017.02.006

  • Most Cited Articles