Abstract
A varied collection of microbes called the soil microbiome plays a major role in various human health issues and sustainable agriculture. Due to its distinct bioactive chemicals and ecological roles, soil microbiota, which is made up of a wide variety of microorganisms such as fungi, bacteria, and archaea, has great promise as therapeutic agents such as antibiotics Streptomycin, Penicillin, Erythromycin, Phosphatase enzymes etc. Moreover, through a variety of mechanisms, including nitrogen fixation, mineralization, solubilization, and nutrient mobilization, these microbes support plants growth. They also generate antagonistic chemicals, siderophores, antimicrobial agents, and hormonal substances that aid in the growth of plants, such as auxin and gibberellins. The goal of low-input agriculture is to increase long-term production while reducing the need for artificial fertilizers and pesticides. Using the possibilities of the soil microbiome promotes healthier surroundings and environmentally friendly agricultural practices, which eventually improve human health. Even though they are among the most diverse species of organisms in this habitat, hardly anything is known about them. Therefore, this study highlight the crucial role of soil microbial diversity that plays an important role in enhancing agricultural productivity, ensuring sustainable food systems, and promoting human health. It seeks to demonstrate how diverse soil microbes improve nutrient cycling, plant growth, and disease resistance, while also supporting ecosystems that are vital for long-term food security.

Key words: Biofertilizers, Bioremediation, Microbiota, Ecosystem, Food Security, Human Health