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Original Article 


Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital

Aditi Singh, Mukesh Kumar Meena, Shailata Prisi, Preeti Chauhan, Ritu Singh, Ankur.


Abstract
Background and Aims:
The LDL-C levels guide the cardiovascular risk assessment under the National Cholesterol Education Program Adult Treatment Panel (NCEP) as well as used for the management of dyslipidemia. Traditionally, LDL-C level is calculated using the Friedewald formula i.e., cLDL, however, recently many of the laboratories have shifted to newer methods of direct LDL-C estimation, i.e., dLDL. With this transition, there is increased demand to compare and establish updated LDL-C level cutoffs for the risk assessments of cardiovascular events.

Methods:
A retrospective observational study, comprising 216 study participants, was conducted in the Department of Biochemistry, Lady Hardinge Medical College, and associated hospitals, in New Delhi for 12 months. Data was collected from 216 adult patients (> 18 years) whose routine fasting lipid profile was done and documented in our clinical biochemistry lab. LDL-C levels done by direct method and calculated methods were compared using the Intraclass correlation coefficient (ICC). Appropriate statistical tests were used with a p-value <0.05 taken as statistically significant.

Results:
When compared between dLDL-C and cLDL-C significant difference was seen with mean values as 104 ±38.8 and 85.5 ±35.6 mg/dl respectively. However, a strong positive correlation was seen between dLDL-C and cLDL-C, r=0.9, p<0.01. The ICC showed good reliability for overall comparison between dLDL-C and cLDL-C, however, reliability was found to be poor for group 2.

Conclusions:
Friedewald and modified Friedewald equations can be used as a substitute for direct homogenous LDL estimation when resources are scarce.

Key words: Direct homogeneous method, Friedewald equation, Lipid profile, LDL, National Cholesterol Education Program Adult Treatment Panel


 
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How to Cite this Article
Pubmed Style

Singh A, Meena MK, Prisi S, Chauhan P, Singh R, Ankur . Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah J Heal Sci. 2024; 12(3): 26-33. doi:10.5455/mjhs.2024.03.004

Web Style

Singh A, Meena MK, Prisi S, Chauhan P, Singh R, Ankur . Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. https://www.mjhs-mu.org/?mno=177962 [Access: September 12, 2024]. doi:10.5455/mjhs.2024.03.004

AMA (American Medical Association) Style

Singh A, Meena MK, Prisi S, Chauhan P, Singh R, Ankur . Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah J Heal Sci. 2024; 12(3): 26-33. doi:10.5455/mjhs.2024.03.004


Vancouver/ICMJE Style

Singh A, Meena MK, Prisi S, Chauhan P, Singh R, Ankur . Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah J Heal Sci. (2024), [cited September 12, 2024]; 12(3): 26-33. doi:10.5455/mjhs.2024.03.004


Harvard Style

Singh, A., Meena, . M. K., Prisi, . S., Chauhan, . P., Singh, . R. & Ankur, . (2024) Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah J Heal Sci, 12 (3), 26-33. doi:10.5455/mjhs.2024.03.004


Turabian Style

Singh, Aditi, Mukesh Kumar Meena, Shailata Prisi, Preeti Chauhan, Ritu Singh, and Ankur. 2024. Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah Journal of Health Sciences, 12 (3), 26-33. doi:10.5455/mjhs.2024.03.004


Chicago Style

Singh, Aditi, Mukesh Kumar Meena, Shailata Prisi, Preeti Chauhan, Ritu Singh, and Ankur. "Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital." Majmaah Journal of Health Sciences 12 (2024), 26-33. doi:10.5455/mjhs.2024.03.004


MLA (The Modern Language Association) Style

Singh, Aditi, Mukesh Kumar Meena, Shailata Prisi, Preeti Chauhan, Ritu Singh, and Ankur. "Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital." Majmaah Journal of Health Sciences 12.3 (2024), 26-33. Print. doi:10.5455/mjhs.2024.03.004


APA (American Psychological Association) Style

Singh, A., Meena, . M. K., Prisi, . S., Chauhan, . P., Singh, . R. & Ankur, . (2024) Does Fredrickson Friedewald’s formula and direct assay of LDL concentration in serum give varying results? - A pilot retrospective study in a tertiary care hospital. Majmaah Journal of Health Sciences, 12 (3), 26-33. doi:10.5455/mjhs.2024.03.004




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