Abstract
Background and Aims:
Adverse Drug Reactions are one of the factors that contribute to hospitalization and death and can be duly prevented and reduced through spontaneous reporting. The study aimed at assessing the knowledge and Practice of Adverse Drug Reaction Reporting among Health Care Practitioners in Primary Health Care Centers in Kano Metropolis.

Methods:
The cross-sectional study used a modified questionnaire that was adapted from similar previous studies with two sections. The total knowledge and practice scores were categorized as good for scores 80% and above, moderate for scores between 60-79% and poor for scores less than 60% using Bloom’s cut-off point. Pearson Chi-square and Fischer-Freeman-Halton Exact Tests, where necessary, were used to test the hypotheses with p < 0.05 set as the level of statistical significance.

Results:
The outcome of the study revealed that though the respondents were aware of pharmacovigilance, only a few (13; 4.4%) understood what pharmacovigilance comprehensively entails. 213(71.7%) have in¬adequate knowledge and 161(71.7%) showed adequate practice of Adverse Drug Reaction reporting. Also, the participants’ cadre significantly influences their knowledge (P-value= 0.026<0.05) and the knowledge of Adverse Drug Reaction significantly influences their practice of Adverse Drug Reaction reporting (P-value=0.031< 0.05).

Conclusions:
Healthcare practitioners are aware of pharmacovigilance but show inadequate knowledge of pharmacovigilance and Adverse Drug Reactions. However, there is an adequate Adverse Drug Reaction reporting practice among the healthcare practitioners. There is a need for continuous mandatory training on Adverse Drug Reactions and reporting, irrespective of the cadre or years of work experience of the health workers.

Key words: Knowledge, Practice, Adverse Drugs Reaction, Healthcare Workers, Nigeria