E-ISSN 1658-8223 | ISSN 1658-645X
 

Original Article 


Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms

Wael H. Alturaiki.

Abstract
Background and Aim: Eosinophils are a key player in allergic inflammation. ECP and IL-4 are essential mediators of allergic inflammation in the lungs and therefore can be used to help in the diagnosis and follow-up of allergic asthma. This study aimed to evaluate whether ECP and IL-4 levels in the plasma of asthmatic patients may reflect the clinical status of asthma exacerbations during sandstorms.

Methods: Thirty patients had allergic asthma, and sixteen normal controls were enrolled in this study. These subjects were divided into two groups. The first group included seventeen patients who had chronic symptoms of asthma but were controlled, and the second group included thirteen patients with chronic symptoms who developed exacerbations during sandstorms. Total IgE, ECP, and IL-4 levels were measured in the plasma of asthmatic patients and normal controls by using specific ELISAs.

Results: Total IgE levels were significantly higher in patients with asthma (mean= 467 IU/ml, P = 0.0001) than in controls (113 IU/ml). IL-4 was not detected in patients with asthma or in controls. ECP levels were elevated significantly in patients with severe symptoms of asthma (mean= 3.28 ng/ml, P=0.0006) in comparison to those in normal controls or patients with controlled asthma (1.9 ng/ml, P=0.02). In addition, there was no significant increase in ECP levels in patients with controlled asthma relative to those
in normal controls.

Conclusions: These findings suggest that ECP but not IL-4 may be a useful marker to evaluate the severity of asthma, follow and predict a response to steroid treatment.

Key words: Asthma, IgE, ECP, IL-4, Eosinophils


 
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How to Cite this Article
Pubmed Style

Wael H. Alturaiki. Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah J Heal Sci. 2020; 8(3): 15-24. doi:10.5455/mjhs.2020.03.004


Web Style

Wael H. Alturaiki. Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. http://www.mjhs-mu.org/?mno=85515 [Access: September 06, 2020]. doi:10.5455/mjhs.2020.03.004


AMA (American Medical Association) Style

Wael H. Alturaiki. Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah J Heal Sci. 2020; 8(3): 15-24. doi:10.5455/mjhs.2020.03.004



Vancouver/ICMJE Style

Wael H. Alturaiki. Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah J Heal Sci. (2020), [cited September 06, 2020]; 8(3): 15-24. doi:10.5455/mjhs.2020.03.004



Harvard Style

Wael H. Alturaiki (2020) Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah J Heal Sci, 8 (3), 15-24. doi:10.5455/mjhs.2020.03.004



Turabian Style

Wael H. Alturaiki. 2020. Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah Journal of Health Sciences, 8 (3), 15-24. doi:10.5455/mjhs.2020.03.004



Chicago Style

Wael H. Alturaiki. "Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms." Majmaah Journal of Health Sciences 8 (2020), 15-24. doi:10.5455/mjhs.2020.03.004



MLA (The Modern Language Association) Style

Wael H. Alturaiki. "Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms." Majmaah Journal of Health Sciences 8.3 (2020), 15-24. Print. doi:10.5455/mjhs.2020.03.004



APA (American Psychological Association) Style

Wael H. Alturaiki (2020) Assessment of plasma ECP levels in Saudi patients with chronic asthma as a marker of asthma exacerbation during sandstorms. Majmaah Journal of Health Sciences, 8 (3), 15-24. doi:10.5455/mjhs.2020.03.004





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