E-ISSN 1658-8223 | ISSN 1658-645X
 

Original Research (Original Article) 


Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients

Naif Al Shahrani.

Abstract
Background: The precise pathogenesis remains not fully understood. However, it is thought to involve an autoimmune process directed against melanocytes. Thyroid disorders and autoimmune thyroid diseases have been shown in some reports to be associated with vitiligo. Additionally, there is limited and conflicting data examining the association of antinuclear antibodies (ANA) with vitiligo.

Methods: We conducted a cross-sectional study among 50 vitiligo patients diagnosed according to established clinical criteria at King Khalid University Hospital, Riyadh from January 2008 through December 2010. Blood samples were obtained from the study participants and were tested for antinuclear antibodies (ANA), thyroid stimulating hormone (TSH) and free thyroxin hormone (T4).

Results: Males represented 62% and the mean age was 28.2±11.0 years. A total of 20 (41.7%) had positive ANA values (titer ≥1:40). The mean TSH level was 2.69±2.17 µIU/mL. The mean free T4 level was 16.40±2.74 pmol/L and all patients were in the normal range (10.3-25.8 pmol/L). There were no statistically significant associations between ANA and age, gender, extent of skin lesion, face inclusion, and free thyroxin levels. On the other hand, positive ANA level had significant association with TSH level (p=0.041). With exception of ANA, TSH level had no statistically significant associations with the above variables.

Conclusions: The results of the current study showed higher prevalence of ANA in vitiligo patients, probably suggesting autoimmune process. The current finding may need to be confirmed in a larger prospective multicentric study before recommending periodic screening of patients with vitiligo for thyroid function and antithyroid antibodies.

Key words: Vitiligo, autoimmune, thyroid disease, antinuclear antibodies


 
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Pubmed Style

Naif Al Shahrani. Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah J Heal Sci. 2014; 2(1): 33-40. doi:10.12816/0004782


Web Style

Naif Al Shahrani. Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. http://www.mjhs-mu.org/?mno=289907 [Access: May 02, 2020]. doi:10.12816/0004782


AMA (American Medical Association) Style

Naif Al Shahrani. Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah J Heal Sci. 2014; 2(1): 33-40. doi:10.12816/0004782



Vancouver/ICMJE Style

Naif Al Shahrani. Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah J Heal Sci. (2014), [cited May 02, 2020]; 2(1): 33-40. doi:10.12816/0004782



Harvard Style

Naif Al Shahrani (2014) Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah J Heal Sci, 2 (1), 33-40. doi:10.12816/0004782



Turabian Style

Naif Al Shahrani. 2014. Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah Journal of Health Sciences, 2 (1), 33-40. doi:10.12816/0004782



Chicago Style

Naif Al Shahrani. "Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients." Majmaah Journal of Health Sciences 2 (2014), 33-40. doi:10.12816/0004782



MLA (The Modern Language Association) Style

Naif Al Shahrani. "Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients." Majmaah Journal of Health Sciences 2.1 (2014), 33-40. Print. doi:10.12816/0004782



APA (American Psychological Association) Style

Naif Al Shahrani (2014) Thyroid Disease and Indicator of Autoimmune Illness Among Vitiligo Patients. Majmaah Journal of Health Sciences, 2 (1), 33-40. doi:10.12816/0004782





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